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KMID : 0356919960300010020
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Korean Journal of Anesthesiology
1996 Volume.30 No. 1 p.20 ~ p.24
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Effects of Sufentanil on Isolated Cardiac Tissure of the Rabbits
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Abstract
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Background:
@EN The synthetic narcotic sufentanil has been used in clinical practice for anesthetic induction and maintenance. But there is little information concerning its direct effects on heart. The purpose of this study is to evaluate the direct effects
of
sufentanil on contracture of ventricular myocardium.
@ES Methods:
@EN Isometric contraction of isolated right ventricular papillary muscle of rabbit was measured under 0.2 Hz electrical stimulation in Kreb's solution. Peak developed force(F0), maximum rate of rise of developed force(+dF/dtmax), maximum rate of
fall
developed force(-dF/dtmax) were analyzed.
@ES Results:
@EN There were no statistically significant differences in frequency of isometric contraction from the 100% baseline value in time-matched control group. Sufentanil, in concentration of 0.01~0.1 mM. increased F0 and -dF/dtmax was decreased
especially
in concentration of 0.1mM but not +dF/dtmax F0, +dF/dtmax and -dF/dtmax were statistically statistically different from time-matched control group in concentration of 0.1mM.
@ES Conclusion:
@EN We conclude that sufentanil has mild contracture effect on ventricular muscle of rabbit directly.
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KEYWORD
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